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2025 POSTER ABSTRACTS
Abstract #
Abstract Title
POSTER SESSION 1: October 8 4:30-6:30 PM ET
NEALS 30TH ABSTRACT | |
1 | RNS60 Protects Neuromuscular Junctions in the Diaphragm Muscle of TDP-43 Associated Amyotrophic Lateral Sclerosis |
2 | Presymptomatic gene expression changes in motor neurons in a large animal model of motor neuron degeneration |
3 | microRNA-206 is a reproducibly sensitive and specific plasma biomarker of amyotrophic lateral sclerosis |
4 | NfL in the NFL: A Prospective Longitudinal Study of Neurofilament Light Chain as a Biomarker of Neurological Injury in Professional Football Players. |
5 | Novel ESR-Based Blood Test for Early ALS Diagnosis Through SOD1 Structural Analysis |
6 | Phenotypic Drug Screening in Human iPSC-Derived Neurons Identifies Modifiers of Dipeptide Repeat-Induced Toxicity and TDP-43 Pathology in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia |
7 | Chloroviruses and ALS |
8 | Discovery and characterisation of a novel inhibitor of the Mitochondrial Permeability Transition Pore in preclinical models of ALS |
9 | ALS-associated circular RNA hsa_circ_0000119 forms a ribonucleoprotein complex enriched with proteins central to ALS pathophysiology |
10 | Investigation of Cortical Hyperexcitability in the Sporadic Form of TDP-43 Pathology Using High-Density Multielectrode Array System |
11 | Characterizing the CSF Biomarker Signature of Calpain-2 Activity in ALS and the Biomarker Impact of Calpain-2 Inhibition in a Preclinical Model of ALS |
12 | Exploratory Post Hoc Analysis of Neutrophil-to-Lymphocyte Ratio as a Novel Responsiveness Biomarker for Edaravone Oral Suspension-Treated Patients With Amyotrophic Lateral Sclerosis vs Untreated Propensity Score-Matched PRO-ACT Historical Placebo Controls |
13 | Electrical Impedance Myography Via the Myolex mScan as an ALS Disease Progression Biomarker: Early Results from the ElectricALS Study |
14 | Dysregulated RNA Transcripts as Blood Biomarkers of ALS |
15 | Incorporating Serum Neurofilament Light Chain into ALS Diagnostic Criteria |
16 | Neurofilament proteoforms in amyotrophic lateral sclerosis are different in cerebrospinal fluid and blood |
17 | An Exploration of Serum Neurofilament Light Chain and Rate of ALSFRS-R Decline |
18 | Longitudinal trajectories of Change of Neurofilament Light Chain in the Answer ALS Cohort |
19 | Neurofilament Light Chain Reflects Clinical and Genetic Heterogeneity in a Real-World ALS Cohort |
20 | Hypermetabolism is common among symptomatic and asymptomatic C9orf72 pathogenic variant carriers and is associated with elevated neurofilament light chain levels |
21 | Predicting ALS survival using combined ALSFRS-R slope and NfL: insights from the ALS/MND Natural History Consortium’s data and biofluid collection study. |
22 | Platelet Proteomics to Identify Novel Biomarkers and Mechanistic Insights in ALS |
23 | Characterizing Microbial Markers Predictive for ALS Onset and Progression |
24 | Access to ALS and FTD biospecimens via NINDS-supported biospecimen repository, BioSEND |
25 | The Accelerating Medicines Partnership® in Amyotrophic Lateral Sclerosis (AMP® ALS) |
26 | Northeast Amyotrophic Lateral Sclerosis (NEALS) Biorepository |
27 | Design and Operationalization of the PREVENT ALL ALS Genetic Testing Sub-Study |
28 | The ANSWER ALS Foundation: Advancing ALS Research Through Strategic Collaboration and Innovation |
29 | ASSESS ALL ALS: A longitudinal, multi-modal natural history study to characterize ALS disease progression using on-site and remote cohorts |
30 | PREVENT ALL ALS: Design for a national ALS gene carrier natural history study |
31 | The Robert Packard Center for ALS Research: 25 Years of Funding Global Collaborative Pre-Clinical Research |
33 | Target ALS Multi-Center Human Postmortem Tissue Core |
34 | ALS cervical cord MRI metanalysis shows flattening of the cervical enlargement region. |
35 | Multicenter imaging study in ALS to demonstrate scalability and clinical trial readiness of multimodal MRI: Preliminary data |
36 | Correlation of Quantitative Susceptibility Mapping with Upper Motor Neuron Dysfunction, Motor Function, and Demographics in Patients with PLS and ALS |
37 | Toward Comprehensive Remote Assessment of ALS Patients: Combining Objective Digital Measures with Patient Reports of Problems |
38 | Reducing Sample Size and Duration of ALS Clinical Trials Using Objective Speech-Based Digital Biomarkers |
39 | Evaluating the Precision of Quantitative Voice Characteristics as Endpoints in ALS Clinical Trials |
40 | Leveraging Integrated Digital Infrastructure to Modernize Remote-Enabled ALS Research: Lessons from the ALL ALS study |
41 | ALS genetic risk predictions using Kolmogorov Arnold Networks |
43 | Quantifying Ambulation in ALS Using Wearable Sensor-Derived Digital Outcomes |
44 | Accelerating ALS Drug Approval using Digital Health Technologies: Findings from the ADDS 2025 ALS Workshop |
45 | Quantifying upper limb function in ALS using wearable sensors during short prescribed exercises |
46 | Design of Digitize ALL ALS: A Wearable Sensor Sub-Study in the ALL ALS Consortium |
47 | Simultaneous bimanual neural control of two cursors by person with tetraplegia with microelectrode arrays in bilateral precentral gyri. |
48 | Rationale for digital health technology assessments in FUNCtion ALS, a Phase 1/2 trial of TRCN-1023, an antisense oligonucleotide restoring UNC13A, in adult persons with Amyotrophic Lateral Sclerosis |
49 | Mobile EEG Meets Generative AI: Benchmarking a Conversational BCI Across ALS and Control Cohorts |
50 | NeuroCHARTS™: A Data-Driven Platform to Streamline Clinical Trial Recruitment |
51 | Facial Stimulus based Virtual Environment BCI for At Home Use in ALS |
52 | A multisensory evoked potential brain-computer interface for amyotrophic lateral sclerosis (ALS) |
53 | Monitoring Neural Correlates of Cognitive Decline in ALS |
55 | Investigating the Relationship Between Cervical Flexor Strength and Tongue Strength in Individuals with Amyotrophic Lateral Sclerosis: A Retrospective Review |
56 | Oral Health and Hygiene in ALS: An Unmet Clinical Need |
57 | Real time Upper Airway Visualization to Improve Tolerance and Adherence to Mechanical Insufflation-Exsufflation in ALS: A Case Study |
58 | Preliminary Results of Combined Respiratory Training to Improve Pulmonary and Cough Function in individuals with ALS |
59 | Toward Automated Cranial Nerve Exam (CNE): Deep Learning-Based Tongue Segmentation in ALS |
60 | Multimodal AI for ALS Bulbar Severity Tracking: A Task and Feature Optimization Approach |
61 | Evaluation of an augmented reality eye-tracking headset for communication in patients with ALS |
62 | Oral Secretion Scale (OSS) - A Multi-National Validated Clinimetric Scale for Assessing State of Secretion Management in NIV-treated ALS Patients Identifies Differences in Secretion Management Device and Medication Use According to Site of ALS Onset |
63 | The Presence of Constipation in Amyotrophic Lateral Sclerosis and Correlation with Disease Characteristics |
64 | Gastrointestinal Symptoms in ALS: Evidence for Enteric Nervous System Involvement and Clinical Implications |
65 | Evaluation of GI tolerance of milk protein- versus plant protein-based enteral nutrition formulas in people with amyotrophic lateral sclerosis (ALS): A multi-site retrospective study |
66 | Factors of Confidence and Regret in Feeding Tube Decision-Making for People Living with Amyotrophic Lateral Sclerosis |
67 | Feeding Tube Placement: An Interdisciplinary Approach |
68 | Is the MIND diet feasible for people living with ALS? A 7-week pilot study of an educational dietary intervention |
69 | Investigation of the Timing of Enteral Nutrition Initiation in patients with tracheostomy invasive ventilation (TIV) |
71 | Improving NIV Use in ALS: A Collaborative Approach to Enhancing Tolerability and Adherence |
72 | The Delta FVC: A potential clinical outcome measure to predict rate of ALS progression |
73 | A yogic breathing program to enhance quality of life in people with amyotrophic lateral sclerosis: A mixed-methods pilot study |
74 | Multicenter Prospective Validation of a Clinical Prediction Tool for Respiratory Insufficiency in ALS: The Pennsylvania Amyotrophic Lateral Sclerosis Cohort Study |
75 | Smartphone Application-Mediated, Supervised, At-Home Telespirometry Identifies Statistically Significant Differences in Erect and Supine Slow Vital Capacity and ALSFRS-R Decline as a Function of Non-invasive Ventilation Treatment Status in Multicenter, Prospective, Longitudinal, Observational Clinical Study [NCT05106569] |
76 | At-Home Telespirometry Identifies Significantly Slower Decline of ALS Functional Rating Scale-Revised Total Score but not Erect/Supine Slow Vital Capacity in Edaravone-Treated ALS Subjects Not Requiring Non-Invasive Ventilation [NCT05106569] |
77 | Assessment of Spirometry Testing Using a Mask for Patients With ALS |
78 | Smartphone Application-Mediated, Respiratory Therapist-Supervised, At-Home Telespirometry Erect/Supine Slow Vital Capacity Measurements in Subjects With ALS: Patient-Reported 5-Item Likert Scale Feasibility and Participation End-of-Study Outcomes Questionnaire Confirms Ease of Implementation and Identifies Per-Subject Benefits |
79 | Predictors of Pneumonia in Motor Neuron Disease: An Exploratory Retrospective Analysis |
81 | Thick Secretions in ALS: What Patients Say |
82 | Cognitive and Behavioral Impairment in ALS: Associations with Survival and Supportive Intervention Uptake |
83 | Depression as a Predictor of ALS Progression and Study Adherence |
84 | Loneliness in ALS: An Exploration of Communication and Mobility Factors |
85 | Development and Preliminary Validation of an ALS-Specific Fatigue Rating Scale |
86 | A Web-based Survey on Lower Urinary Tract Symptoms in Amyotrophic Lateral Sclerosis |
87 | Clinical Decision-Making in Amyotrophic Lateral Sclerosis Rehabilitation: A Physical Therapy Practice Pattern Survey |
88 | Caring for the Homebound Patient with ALS |
89 | Preliminary Outcomes of Early Neuromuscular Rehabilitation in SOD1 ALS Patients Receiving Tofersen: A 6-Month Observational Study |
90 | Impact of Assisted Foam Rolling on Lower Limb Performance in Advanced ALS: A Case Report |
91 | Design of a minimal neck brace for pALS with Dropped Head Syndrome |
92 | Perspectives of Persons Living with ALS: A Thematic Analysis Across Clinical and Psychosocial Domains |
93 | A Report on the Relationship Between ALS Diagnostic Delay and Depression/Anxiety Symptoms |
94 | Cognitive Compass: Guiding ALS Patient Care with Interdisciplinary Neuropsychology |
95 | Informants (Study Partners) in presymptomatic FTD/ALS Research: Highlighting uncharacterized and uncommunicated potential risks |
96 | Navigating Complex Conversations in ALS |
97 | Exploring Palliative Care Needs in Amyotrophic Lateral Sclerosis. Perspectives from Patients and Caregivers: A Scoping Review. |
98 | A Novel Exploration of Sexual Behavior and Intimacy in Amyotrophic Lateral Sclerosis: One-Year Study Update |
135 | Unprecedented Progression of fALS with SOD1 and PFN1 Mutations: A Novel Case Report |
99 | Characteristics and Disease Burden of People With Amyotrophic Lateral Sclerosis in a United States-Based Population: Analysis of Real-World Data |
100 | Primary Reasons for Emergency Room Visits and Discharge Dispositions in Patients with Amyotrophic Lateral Sclerosis (ALS) at the Massachusetts General Hospital |
101 | Exploring Pain Management Procedures for Musculoskeletal Issues in Patients with Amyotrophic Lateral Sclerosis (ALS): A Retrospective Chart Review |
102 | Tofersen-associated Radiculitis in SOD1-ALS Effectively Managed with IV but not IT Corticosteroid Administration |
103 | Radiological characterization of tofersen-associated myelitis: a case report |
104 | The VITALS Trial: Comparing the Impact of Video Integration to Traditional Amyotrophic Lateral Sclerosis Visit Communication on Patient and Caregiver Quality of Life |
105 | The Feasibility and Acceptability of Sharing Video Recordings of Amyotrophic Lateral Sclerosis Clinical Encounters With Patients and Their Caregivers: Pilot Randomized Clinical Trial |
106 | A Pilot Study of Remotely-Administered Cognitively-Based Compassion Training (CBCT®) for People Living with ALS (pALS) and their Care Partners |
212 | Examining IGFBP7 as a Potential Therapeutic Target in People with ALS |
213 | Advanced base and prime editing strategies to correct common ALS-causing SOD1 mutations |
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Abstract #
Abstract Title
209 | ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments |
210 | ACT for ALS EAPs by the Numbers |
211 | Development of LTX-002, a novel ASO for the treatment of ALS |
212 | Examining IGFBP7 as a Potential Therapeutic Target in People with ALS |
213 | Advanced base and prime editing strategies to correct common ALS-causing SOD1 mutations |
POSTER SESSION 2: October 9 4:20-6:20 PM ET
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POSTER AWARDS
Basic Science Abstract Award
The Basic Science Abstract Award will be given to an outstanding abstract poster presentation focused on basic science.
Clinical Investigation Abstract Award
The Clinical Investigation Abstract Award will be given to an exceptional abstract poster presenter focused on clinical investigation.
UMN Achievement Award
The seventh annual UMN Achievement Award will be given to two abstracts focusing on PLS/UMN research. The UMN Achievement Award is supported by the Spastic Paraplegia Foundation (SPF) to promote UMN research and recognize those who contribute significantly to this field.
SCIENCE HIGHLIGHTS
Science Symposium Presentation
Up to 2 abstract submissions focusing on sporadic ALS will be selected for 10-minute presentations during the Science Symposium portion of our conference.
Lightening Science Talks
Up to 12 abstract submissions will be selected for 3-minute presentations during the conference.
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